Nonsteroidal Anti-inflammatory Drug-related Gastrointestinal Bleeding in the Elderly

Nonsteroidal Anti-inflammatory Drug-related Gastrointestinal Bleeding in the Elderly

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Nonsteroidal anti-inflammatory drug (NSAID) could induce gastrointestinal (GI) injury by way of topical (mucus, gastric acid and drug interaction) and systemic mechanism (decreased prostaglandin synthesis).Compared with non-NSAID users, elderly taking NSAID or aspirin have a higher chance than younger people of developing GI bleeding (5.5-fold vs.1.

65-fold).Endoscopy is the best tool to identify the source and severity of ulcer with bleeding.The use of NSAID or aspirin should be weighed carefully in elderly beetroot birkenstock who have a history of peptic ulcer.If necessary, it is better to choose cyclooxygenase-2 inhibitor since it has been reported that the drug has less than half the risk of non-selective NSAID to ignite GI complications.

Eradication of underwater treasures sunken medallion Helicobacter pylori might reduce ulcer risk in new NSAID users, but not in patients with long-term therapy.Proton pump inhibitor is the drug of choice that is effective for both treatment and prevention (taken together with NSAID) of NSAID-related GI bleeding.